New bio-Plastic production

Toxic metal tolerant Ralstonia eutropha  to produce polyhydroxyalkanote (PHA) bioplastics

PHA is currently produced from corn and sugar cane and requires high water consumption.

One one side the mentioned crops could be better used for human consumption , on the other land and water employiment is not sustainable.

Our approach will lead to : 46 times less water use and 24 times less land use.


The overall development of the ENGICOIN bioreactor will integrate different components:

  • strain development through the usage of a variety of tools available for systems metabolic engineering (e.g. systems biology, synthetic biology and evolutionary engineering;
  • engineering of midstream (fermentation) and,
  • downstream (separation and purification) processes.

Our process is simply effective

Our engineering foresees diverse systems metabolic engineering techniques which will be chosen according to their suitability to the specific purposes and which will encompass both the modulation of pathways inherent to the host strain (by e.g. transporter engineering, pathway rerouting, cofactor optimization, promoter engineering, and enzyme evolution for activity optimization) and the establishment of de novo pathway.

it can produce PHA

Please, meet Ralstonia eutropha!


Basically, bio-plastic highly ductile and elastic.
This project has received funding from the European Union's Horizon 2020 Research and Innovation Programme under Grant Agreement No. 760994.
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