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Innovative Lactic Acid

Cyanobacterium Synechocystis to produce lactic acid (LA) as a polylactate (PL) plastics precursor.

What we will do in a nutshell

TRL 5 aerobic photobioreactor reliant on engineered Synechocystis strains to produce enantiopure L-lactic acid, which is the precursor of polylactate bioplastics, providing the best potential economic margin according to PHO, from CO2 and driven by solar radiation during daylight hours and/or LED radiation (e.g. during night-time hours). Operating the photobioreactor exploiting both solar and artificial light is enabled by the envisaged highly integrated processes’ scheme, which will power LEDs from low-price electricity derived from a biogas engine based cogeneration unit.

The main factors we want to capture in the concept design of the MF1 (arbitrarily ordered) are:

  • increase lactic acid tolerance;
  • elimination of competing substrate-consuming pathways;
  • increase of substrate availability for the lactate dehydrogenase (LDH) enzyme;
  • optimize expression of LDH using systems that respond to cues that are industrially relevant;
  • modulate activity of LDH using recently identified allosteric effectors;
  • increase photosynthetic efficiency of production strains by the broadening of their absorption spectrum;
  • optimize the minerals requirement during production
  • optimize/ select the optimal conditions for the purification of lactic acid.
The ultimate goal is to design strains, encompassing metabolic engineering strategies that are predicted to lead to stable and robust production of the target compound Lactic acid at the highest titres and productivities possible.

Advanced Chemicals


Skilled team


Innovative tech