UvA will have a primary role in WP4 in the metabolic engineering of the Synechocystis (MF1). There it will be responsible for engineering and screening lactate-overproducing strains and along with increasing its product tolerance, for instance, using laboratory evolution approaches. UvA has pioneered the production of lactate directly from CO2. More recently, UvA has also been using laboratory evolution to improve industrial traits .
UvA will also have a major role in WP9 on the metabolic modelling of Synechocystis to ensure high-level production of lactate.