Kungliga Tekniska Hoegskolan
The Swedish Royal Institute of Technology (KTH) participates in ENGICOIN via the School of Biotechnology which is focused on health and environmental research and offers state-of-the-art infrastructure for high-throughput systems biology. Particularly, KTH takes part to the ENGICOIN project through the laboratory led by Prof. Hudson. Research is focused on the metabolism of bacteria that fix carbon dioxide. Energy sources for these bacteria can be sunlight, hydrogen, other gases, or metals. The main focus is on photosynthetic cyanobacteria and hydrogen oxidizing bacteria that use the Calvin Cycle. The final goal is to engineer the metabolism so that these bacteria fix CO2 and can convert it into chemicals and fuels at high rates. To do this, the group is expert in metabolic engineering, synthetic biology, and systems biology.
Team role and expertise in the project
Within the ENGICOIN project, KTH is active in WP 4 for development of a photosynthetic cell factory producing lactate thanks in metabolic engineering of cyanobacteria by means of gene editing tools, genome scale metabolic modelling, and systems-biology analysis of gene expression during stress.